{"product_id":"epithalon-20mg-vial-bodypharm-copy","title":"MOTS-C 10mg Vial - BodyPharm","description":"\u003cdiv class=\"text-xs text-muted-foreground italic\"\u003e\u003cbr\u003e\u003c\/div\u003e\n\u003cdiv class=\"text-xs text-muted-foreground italic\"\u003e\n\u003cmeta charset=\"utf-8\"\u003e \u003cmeta charset=\"utf-8\"\u003e \u003cmeta charset=\"utf-8\"\u003e\n\u003ch1 data-path-to-node=\"0\"\u003eMOTS-c (Mitochondrial-Derived Peptide) | Educational Overview\u003c\/h1\u003e\n\u003ch2 data-path-to-node=\"1\"\u003eWhat is MOTS-c?\u003c\/h2\u003e\n\u003cp data-path-to-node=\"2\" id=\"p-rc_afd05c0005701ccc-33\"\u003e\u003cspan class=\"citation-59 citation-end-59\"\u003eMOTS-c (Mitochondrial Open Reading Frame of the 12S rRNA type-c) is a naturally occurring 16-amino-acid peptide.\u003csup class=\"superscript\" data-turn-source-index=\"1\"\u003e\u003c!----\u003e\u003c\/sup\u003e\u003c\/span\u003e \u003cspan class=\"citation-58\"\u003eUnlike the vast majority of peptides encoded by DNA inside the cell's nucleus, MOTS-c is unique because it is encoded entirely within the \u003c\/span\u003e\u003cb data-path-to-node=\"2\" data-index-in-node=\"251\"\u003e\u003cspan class=\"citation-58\"\u003emitochondrial genome\u003c\/span\u003e\u003c\/b\u003e\u003cspan class=\"citation-58 citation-end-58\"\u003e.\u003csup class=\"superscript\" data-turn-source-index=\"2\"\u003e\u003c!----\u003e\u003c\/sup\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003cdiv class=\"source-inline-chip-container luminous-sources hide-from-message-actions ng-star-inserted\"\u003e\n\u003cbutton class=\"button multiple-button ng-star-inserted\" aria-label=\"View source details for citations from PMC - NIH and Intricate Art Spine \u0026amp; Body Solutions. Opens side panel.\"\u003e\u003c!----\u003e\u003c\/button\u003e\n\u003cdiv class=\"source-label-container gds-label-m ng-star-inserted\" dir=\"ltr\"\u003e\n\u003cbdi class=\"source-title\"\u003ePMC - NIH\u003c\/bdi\u003e\u003cspan dir=\"ltr\" class=\"source-count ng-star-inserted\"\u003e+ 1\u003c\/span\u003e\u003c!----\u003e\n\u003c\/div\u003e\n\u003cbutton class=\"button multiple-button ng-star-inserted\" aria-label=\"View source details for citations from PMC - NIH and Intricate Art Spine \u0026amp; Body Solutions. Opens side panel.\"\u003e\u003c!----\u003e\u003c!----\u003e\u003c!----\u003e\u003c!----\u003e\u003c\/button\u003e\u003c!----\u003e\u003c!----\u003e\u003c!----\u003e\u003c!----\u003e\n\u003c\/div\u003e\n\u003ch3 data-start=\"32\" data-end=\"125\"\u003e\n\u003c!----\u003e\u003c!----\u003e\u003c!----\u003e\u003c!----\u003e\u003c!----\u003e\u003c!----\u003e\u003c!----\u003e\u003c!----\u003e\n\u003c\/h3\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003cp data-path-to-node=\"3\" id=\"p-rc_afd05c0005701ccc-34\"\u003e\u003cspan class=\"citation-57 citation-end-57\"\u003eOften called an \"exercise mimetic,\" MOTS-c acts as a critical metabolic signaling molecule that regulates systemic energy balance, cellular resilience, and bidirectional communication between the mitochondria and the nucleus.\u003csup class=\"superscript\" data-turn-source-index=\"3\"\u003e\u003c!----\u003e\u003c\/sup\u003e\u003c\/span\u003e Endogenous (natural) levels of MOTS-c rise dramatically during physical stress or exercise, but they naturally decline as part of the aging process.\u003c\/p\u003e\n\u003cdiv class=\"source-inline-chip-container luminous-sources hide-from-message-actions ng-star-inserted\"\u003e\n\u003cbutton class=\"button multiple-button ng-star-inserted\" aria-label=\"View source details for citation from Intricate Art Spine \u0026amp; Body Solutions. Opens side panel.\"\u003e\u003c!----\u003e\u003c\/button\u003e\n\u003cdiv class=\"source-label-container gds-label-m ng-star-inserted\" dir=\"ltr\"\u003e\n\u003cbdi class=\"source-title\"\u003eIntricate Art Spine \u0026amp; Body Solutions\u003c\/bdi\u003e\u003c!----\u003e\n\u003c\/div\u003e\n\u003cbutton class=\"button multiple-button ng-star-inserted\" aria-label=\"View source details for citation from Intricate Art Spine \u0026amp; Body Solutions. Opens side panel.\"\u003e\u003c!----\u003e\u003c!----\u003e\u003c!----\u003e\u003c!----\u003e\u003c\/button\u003e\u003c!----\u003e\u003c!----\u003e\u003c!----\u003e\u003c!----\u003e\n\u003c\/div\u003e\n\u003ch3 data-start=\"32\" data-end=\"125\"\u003e\n\u003c!----\u003e\u003c!----\u003e\u003c!----\u003e\u003c!----\u003e\u003c!----\u003e\u003c!----\u003e\u003c!----\u003e\u003c!----\u003e\n\u003c\/h3\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003ch2 data-path-to-node=\"5\"\u003eKey Benefits \u0026amp; Mechanisms of Action\u003c\/h2\u003e\n\u003ch3 data-path-to-node=\"6\"\u003e1. \u003cspan class=\"citation-56 citation-end-56\"\u003eRobust Activation of the AMPK Pathway\u003csup class=\"superscript\" data-turn-source-index=\"4\"\u003e\u003c!----\u003e\u003c\/sup\u003e\u003c\/span\u003e\n\u003c\/h3\u003e\n\u003cp data-path-to-node=\"7\" id=\"p-rc_afd05c0005701ccc-35\"\u003e\u003cspan class=\"citation-55\"\u003eThe primary mechanism of MOTS-c is the activation of AMP-activated protein kinase (AMPK), often described as the body's \u003c\/span\u003e\u003cb data-path-to-node=\"7\" data-index-in-node=\"120\"\u003e\u003cspan class=\"citation-55 citation-end-55\"\u003e\"master metabolic switch.\"\u003c\/span\u003e\u003c\/b\u003e\u003cb data-path-to-node=\"7\" data-index-in-node=\"120\"\u003e\u003cspan class=\"citation-55 citation-end-55\"\u003e\u003c\/span\u003e\u003c\/b\u003e\u003c\/p\u003e\n\u003cul data-path-to-node=\"8\"\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"8,0,0\" id=\"p-rc_afd05c0005701ccc-36\"\u003e\u003cb data-path-to-node=\"8,0,0\" data-index-in-node=\"0\"\u003eGlucose Uptake:\u003c\/b\u003e\u003cspan class=\"citation-54 citation-end-54\"\u003e It signals skeletal muscle tissues to clear glucose from the bloodstream and utilize it efficiently for energy, closely mirroring the action of the first-line metabolic medication metformin.\u003csup class=\"superscript\" data-turn-source-index=\"6\"\u003e\u003c!----\u003e\u003c\/sup\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"8,1,0\" id=\"p-rc_afd05c0005701ccc-37\"\u003e\u003cspan class=\"citation-53\"\u003e\u003c\/span\u003e\u003cb data-path-to-node=\"8,1,0\" data-index-in-node=\"0\"\u003e\u003cspan class=\"citation-53\"\u003eFatty Acid Oxidation:\u003c\/span\u003e\u003c\/b\u003e\u003cspan class=\"citation-53 citation-end-53\"\u003e It enhances the expression of carnitine shuttles, which transport fatty acids into the mitochondria to be broken down (beta-oxidation) for fuel, helping to prevent lipid accumulation in tissues.\u003csup class=\"superscript\" data-turn-source-index=\"7\"\u003e\u003c!----\u003e\u003c\/sup\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003cdiv class=\"source-inline-chip-container luminous-sources hide-from-message-actions ng-star-inserted\"\u003e\n\u003cbr\u003e\u003cbutton class=\"button multiple-button ng-star-inserted\" aria-label=\"View source details for citation from iPharma Pharmacy. Opens side panel.\"\u003e\u003c!----\u003e\u003c!----\u003e\u003c!----\u003e\u003c!----\u003e\u003c\/button\u003e\u003c!----\u003e\u003c!----\u003e\u003c!----\u003e\u003c!----\u003e\n\u003c\/div\u003e\n\u003c!----\u003e\u003c!----\u003e\u003c!----\u003e\u003c!----\u003e\u003c!----\u003e\u003c!----\u003e\u003c!----\u003e\u003c!----\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch3 data-path-to-node=\"9\"\u003e2. Cellular Longevity and Anti-Aging\u003c\/h3\u003e\n\u003cp data-path-to-node=\"10\" id=\"p-rc_afd05c0005701ccc-38\"\u003e\u003cspan class=\"citation-52 citation-end-52\"\u003eBecause it addresses mitochondrial dysfunction—a primary hallmark of aging—preclinical research has highlighted its potential to support healthspan:\u003c\/span\u003e\u003cbutton class=\"button multiple-button ng-star-inserted\" aria-label=\"View source details for citation from Innerbody Research. Opens side panel.\"\u003e\u003c!----\u003e\u003c!----\u003e\u003c!----\u003e\u003c!----\u003e\u003c\/button\u003e\u003c!----\u003e\u003c!----\u003e\u003c!----\u003e\u003c!----\u003e\u003c\/p\u003e\n\u003ch3 data-start=\"32\" data-end=\"125\"\u003e\n\u003c!----\u003e\u003c!----\u003e\u003c!----\u003e\u003c!----\u003e\u003c!----\u003e\u003c!----\u003e\u003c!----\u003e\u003c!----\u003e\n\u003c\/h3\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003cul data-path-to-node=\"11\"\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"11,0,0\" id=\"p-rc_afd05c0005701ccc-39\"\u003e\u003cb data-path-to-node=\"11,0,0\" data-index-in-node=\"0\"\u003ePhysical Capacity:\u003c\/b\u003e\u003cspan class=\"citation-51 citation-end-51\"\u003e In animal models, regular administration demonstrated marked improvements in grip strength, motor coordination, and endurance across all age brackets.\u003csup class=\"superscript\" data-turn-source-index=\"9\"\u003e\u003c!----\u003e\u003c\/sup\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003cdiv class=\"source-inline-chip-container luminous-sources hide-from-message-actions ng-star-inserted\"\u003e\n\u003cbr\u003e\u003cbutton class=\"button multiple-button ng-star-inserted\" aria-label=\"View source details for citation from Innerbody Research. Opens side panel.\"\u003e\u003c!----\u003e\u003c!----\u003e\u003c!----\u003e\u003c!----\u003e\u003c\/button\u003e\u003c!----\u003e\u003c!----\u003e\u003c!----\u003e\u003c!----\u003e\n\u003c\/div\u003e\n\u003c!----\u003e\u003c!----\u003e\u003c!----\u003e\u003c!----\u003e\u003c!----\u003e\u003c!----\u003e\u003c!----\u003e\u003c!----\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"11,1,0\" id=\"p-rc_afd05c0005701ccc-40\"\u003e\u003cspan class=\"citation-50\"\u003e\u003c\/span\u003e\u003cb data-path-to-node=\"11,1,0\" data-index-in-node=\"0\"\u003e\u003cspan class=\"citation-50\"\u003eTissue Preservation:\u003c\/span\u003e\u003c\/b\u003e\u003cspan class=\"citation-50 citation-end-50\"\u003e Studies indicate it plays a role in suppressing myostatin (an inhibitor of muscle growth) to combat age-related muscle wasting (sarcopenia), while supporting osteoblast differentiation to preserve bone density.\u003csup class=\"superscript\" data-turn-source-index=\"10\"\u003e\u003c!----\u003e\u003c\/sup\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003c!----\u003e\u003c!----\u003e\u003c!----\u003e\u003c!----\u003e\u003c!----\u003e\u003c!----\u003e\u003c!----\u003e\u003c!----\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch3 data-path-to-node=\"12\"\u003e3. Adaptive Stress Resistance\u003c\/h3\u003e\n\u003cp data-path-to-node=\"13\" id=\"p-rc_afd05c0005701ccc-41\"\u003e\u003cspan class=\"citation-49 citation-end-49\"\u003eWhen a cell undergoes metabolic stress, MOTS-c translocates directly into the cell nucleus to upregulate adaptive stress-response genes, boosting endogenous antioxidant pathways and downregulating pro-inflammatory markers.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp data-path-to-node=\"13\"\u003e \u003c\/p\u003e\n\u003ch2 data-path-to-node=\"15\"\u003eTheoretical Dosing Guidelines (Research Use Only)\u003c\/h2\u003e\n\u003cblockquote data-path-to-node=\"16\"\u003e\n\u003cp data-path-to-node=\"16,0\" id=\"p-rc_afd05c0005701ccc-42\"\u003e\u003cb data-path-to-node=\"16,0\" data-index-in-node=\"0\"\u003eImportant Regulatory Note:\u003c\/b\u003e\u003cspan class=\"citation-48 citation-end-48\"\u003e MOTS-c remains an experimental compound and is not approved by the FDA or international regulatory bodies for human use.\u003csup class=\"superscript\" data-turn-source-index=\"12\"\u003e\u003c!----\u003e\u003c\/sup\u003e\u003c\/span\u003e The protocols below reflect common dosing parameters established within prevailing preclinical models, literature reviews, and clinical research contexts.\u003c\/p\u003e\n\u003c\/blockquote\u003e\n\u003cp data-path-to-node=\"17\"\u003e \u003c\/p\u003e\n\u003cp data-path-to-node=\"17\"\u003eBecause MOTS-c possesses a short half-life and acts primarily on systemic skeletal muscle tissue, it is typically administered via \u003cb data-path-to-node=\"17\" data-index-in-node=\"131\"\u003esubcutaneous (SQ)\u003c\/b\u003e injection.\u003c\/p\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"text-xs text-muted-foreground italic\"\u003e\u003cbr\u003e\u003c\/div\u003e\n\u003cdiv class=\"text-xs text-muted-foreground italic\"\u003eFor research and analytical purposes only\u003c\/div\u003e\n\u003cdiv class=\"text-xs text-muted-foreground italic\"\u003e\u003cbr\u003e\u003c\/div\u003e\n\u003cdiv\u003e\u003cstrong\u003eImportant Note: We do not keep stock of this product and order stock on Mondays. All orders will only be process once stock is received and might cause a longer delivery time. Delivery can take 5 – 10 working days depending on when you place the order and where you are based.\u003c\/strong\u003e\u003c\/div\u003e\n\u003cdiv\u003e\n\u003cstrong\u003e\u003c\/strong\u003e\u003cbr\u003e\n\u003c\/div\u003e\n\u003cp data-start=\"641\" data-end=\"820\"\u003e \u003c\/p\u003e\n\u003chr data-start=\"2052\" data-end=\"2055\"\u003e\n\u003ch3 data-start=\"2057\" data-end=\"2082\"\u003eImportant Information\u003c\/h3\u003e\n\u003cul data-start=\"2083\" data-end=\"2441\"\u003e\n\u003cli data-start=\"2083\" data-end=\"2145\"\u003e\n\u003cp data-start=\"2085\" data-end=\"2145\"\u003eThis product is supplied in a \u003cstrong data-start=\"2115\" data-end=\"2145\"\u003elyophilised peptide format\u003c\/strong\u003e\u003cbr\u003e\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli data-start=\"2266\" data-end=\"2367\"\u003e\n\u003cp data-start=\"2268\" data-end=\"2367\"\u003eConsultation with a \u003cstrong data-start=\"2288\" data-end=\"2320\"\u003elicensed healthcare provider\u003c\/strong\u003e is essential prior to any consideration of use\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli data-start=\"2368\" data-end=\"2441\"\u003e\n\u003cp data-start=\"2370\" data-end=\"2441\"\u003eResults observed in clinical trials may not reflect real-world outcomes\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003chr data-start=\"2443\" data-end=\"2446\"\u003e\n\u003ch3 data-start=\"2448\" data-end=\"2481\"\u003e\u003cbr\u003e\u003c\/h3\u003e\n\u003cp data-start=\"2482\" data-end=\"2588\"\u003eThis product is supplied strictly on an \u003cstrong data-start=\"2522\" data-end=\"2550\"\u003einformed purchaser basis\u003c\/strong\u003e. By purchasing, you acknowledge that:\u003c\/p\u003e\n\u003cul data-start=\"2590\" data-end=\"3029\"\u003e\n\u003cli data-start=\"2590\" data-end=\"2671\"\u003e\n\u003cp data-start=\"2592\" data-end=\"2671\"\u003eYou have independently researched this product and its investigational status\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli data-start=\"2672\" data-end=\"2748\"\u003e\n\u003cp data-start=\"2674\" data-end=\"2748\"\u003eYou have consulted, or will consult, a qualified healthcare professional\u003cbr\u003e\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli data-start=\"2860\" data-end=\"2943\"\u003e\n\u003cp data-start=\"2862\" data-end=\"2943\"\u003eThe seller provides \u003cstrong data-start=\"2882\" data-end=\"2941\"\u003eno medical advice, treatment claims, or dosing guidance\u003c\/strong\u003e\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli data-start=\"2944\" data-end=\"3029\"\u003e\n\u003cp data-start=\"2946\" data-end=\"3029\"\u003eThe \u003cstrong data-start=\"2950\" data-end=\"3029\"\u003eonus of lawful, safe, and appropriate use rests entirely with the purchaser\u003c\/strong\u003e\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e","brand":"LIFE.OS","offers":[{"title":"Default Title","offer_id":53542423724350,"sku":"BPMOTSC10MG","price":490.0,"currency_code":"ZAR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0970\/9826\/8990\/files\/BPTB50010MG_1.png?v=1779709127","url":"https:\/\/life-os.co.za\/products\/epithalon-20mg-vial-bodypharm-copy","provider":"LIFE.OS","version":"1.0","type":"link"}